Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates. - Wikidata - awgldk - TriplyDB

Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates.

Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates.

http://www.wikidata.org/entity/Q37755154

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Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma

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Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates.

http://www.wikidata.org/entity/Q37755154

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Theme: oncology--molecular mec ...... identify biomarker candidates.

@en

Theme: oncology--molecular mec ...... identify biomarker candidates.

@nl

type

label

Theme: oncology--molecular mec ...... identify biomarker candidates.

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Theme: oncology--molecular mec ...... identify biomarker candidates.

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prefLabel

Theme: oncology--molecular mec ...... identify biomarker candidates.

@en

Theme: oncology--molecular mec ...... identify biomarker candidates.

@nl

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Biomarkers in Medicine

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Theme: oncology--molecular mec ...... identify biomarker candidates.

@en

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Mai Yamauchi

http://www.w3.org/2001/XMLSchema#string

Noriko Gotoh

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

Somatic mutations affect key pathways in lung adenocarcinoma

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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139-151

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scholarly article

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10.2217/BMM.09.9

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2

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3

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2009-04-01T00:00:00Z

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20477507

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