The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer.
about
Developmental disease and cancer: biological and clinical overlapsCohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatinA novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cellsTwo-step ATP-driven opening of cohesin headOverall and allele-specific expression of the SMC1A gene in female Cornelia de Lange syndrome patients and healthy controlsGenetic adaptation associated with genome-doubling in autotetraploid Arabidopsis arenosa.Micromechanics of human mitotic chromosomes.Sister chromatid cohesion establishment occurs in concert with lagging strand synthesis.RAD21 mutations cause a human cohesinopathyIn vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.Proteomic profile identifies dysregulated pathways in Cornelia de Lange syndrome cells with distinct mutations in SMC1A and SMC3 genes.Sister chromatid cohesionReduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability.The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins.Epigenetic deregulation of the LMP1/LMP2 locus of Epstein-Barr virus by mutation of a single CTCF-cohesin binding site.Sister chromatid cohesion control and aneuploidy.pRB, a tumor suppressor with a stabilizing presence.Challenges in studying genomic structural variant formation mechanisms: the short-read dilemma and beyond.RB: mitotic implications of a tumour suppressor.Cohesin regulates MHC class II genes through interactions with MHC class II insulators.Genome stability: What we have learned from cohesinopathies.Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome.siRNA-mediated knockdown of SMC1A expression suppresses the proliferation of glioblastoma cells.SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins.Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latency.Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications.Familial skewed X-chromosome inactivation linked to a component of the cohesin complex, SA2.STAG2 expression in oral cancer and potentially malignant lesions.Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.Mutant cohesin drives chromosomal instability in early colorectal adenomas.SMC1A codon 496 mutations affect the cellular response to genotoxic treatments.Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion.Impairment of Retinoic Acid Signaling in Cornelia de Lange Syndrome Fibroblasts
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The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The expanding universe of cohe ...... d in human disease and cancer.
@en
The expanding universe of cohe ...... d in human disease and cancer.
@nl
type
label
The expanding universe of cohe ...... d in human disease and cancer.
@en
The expanding universe of cohe ...... d in human disease and cancer.
@nl
prefLabel
The expanding universe of cohe ...... d in human disease and cancer.
@en
The expanding universe of cohe ...... d in human disease and cancer.
@nl
P356
P1433
P1476
The expanding universe of cohe ...... ed in human disease and cancer
@en
P2093
Linda Mannini
Stefania Menga
P304
P356
10.1002/HUMU.21252
P577
2010-06-01T00:00:00Z