Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

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http://www.wikidata.org/entity/Q37765082
The paradox of conformational constraint in the design of Cbl(TKB)-binding peptidesChallenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain.Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo modelsInduction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer.H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemiaCBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2.c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus.Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro.CBL RING finger deletions are common in core-binding factor acute myeloid leukemias.A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease.CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors.Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia.Juvenile myelomonocytic leukemia due to a germline CBL Y371C mutation: 35-year follow-up of a large family.
P2860

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

Item
http://www.wikidata.org/entity/Q37765082
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 June 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
@en
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
@nl
type
label
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
@en
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
@nl
prefLabel
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
@en
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms
@en
P2093
P304
P31
P356
10.1158/1078-0432.CCR-09-2341
P407
P433
P478
P50
P577
P698