Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
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Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutationLRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in miceFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyPlant mitochondrial dynamics and the role of membrane lipidsThe dynamics of the mitochondrial organelle as a potential therapeutic targetMitochondrial structure, function and dynamics are temporally controlled by c-MycAltered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fissionDrp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivoDynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fissionCeramide induced mitophagy and tumor suppressionSpecific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologiesMitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal culturesThe mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse.Mitochondrial dynamics and motility inside living vascular endothelial cells: role of bioenergetics.Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis.Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission-fusion balance within mitochondrial networks.Actin filaments as dynamic reservoirs for Drp1 recruitment.microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor.A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission.Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model.Novel roles for actin in mitochondrial fissionEmergence of the mitochondrial reticulum from fission and fusion dynamics.GSK3beta-mediated Drp1 phosphorylation induced elongated mitochondrial morphology against oxidative stress.Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model.Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons.Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neuronsParkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.Mitochondrial fission augments capsaicin-induced axonal degenerationPersistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell deathEffect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model.How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenarioMitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cellsMitochondrial quality control and dynamics in Parkinson's diseaseFuse or die: Shaping mitochondrial fate during starvation.Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
P2860
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P2860
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dynamic regulation of mitochon ...... e dynamin-related protein Drp1
@en
Dynamic regulation of mitochon ...... dynamin-related protein Drp1.
@nl
type
label
Dynamic regulation of mitochon ...... e dynamin-related protein Drp1
@en
Dynamic regulation of mitochon ...... dynamin-related protein Drp1.
@nl
prefLabel
Dynamic regulation of mitochon ...... e dynamin-related protein Drp1
@en
Dynamic regulation of mitochon ...... dynamin-related protein Drp1.
@nl
P2860
P1476
Dynamic regulation of mitochon ...... e dynamin-related protein Drp1
@en
P2093
Craig Blackstone
P2860
P356
10.1111/J.1749-6632.2010.05629.X
P407
P577
2010-07-01T00:00:00Z