A review of the electrophilic reaction chemistry involved in covalent DNA binding.
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Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic researchNovel in vitro and mathematical models for the prediction of chemical toxicityMechanisms of chemical carcinogenesis in the kidneysGlutathione peroxidase inhibitory assay for electrophilic pollutants in diesel exhaust and tobacco smokeAlternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Strategies for the generation, validation and application of in silico ADMET models in lead generation and optimization.In silico toxicology - non-testing methods.Formation and signaling actions of electrophilic lipidsThe macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural productCharacterization of Interstrand DNA-DNA Cross-Links Using the α-Hemolysin Protein NanoporeGenotoxicity-related chemistry of human metabolites of benzo[ghi]perylene (B[ghi]P) investigated using electro-optical arrays and DNA/microsome biocolloid reactors with LC-MS/MSA review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity.The influence of the 'organizational factor' on compound quality in drug discovery.A review of the use of in silico methods to predict the chemistry of molecular initiating events related to drug toxicity.Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities.Taking Advantage of Databases.Mutagenic and carcinogenic structural alerts and their mechanisms of action.Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate CancerOrigin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation.In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects.Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife.General baseline toxicity QSAR for nonpolar, polar and ionisable chemicals and their mixtures in the bioluminescence inhibition assay with Aliivibrio fischeri.Evaluation of QSAR models for the prediction of ames genotoxicity: a retrospective exercise on the chemical substances registered under the EU REACH regulation.Experimental verification, and domain definition, of structural alerts for protein binding: epoxides, lactones, nitroso, nitros, aldehydes and ketones.The definition of the toxicologically relevant applicability domain for the SNAr reaction for substituted pyridines and pyrimidines.Integrated in silico approaches for the prediction of Ames test mutagenicity.Использование интеллектуальной ДСМ-системы для анализа связи структуры нитрозамещенных бензолов с их мутагенной активностью в тесте Эймса
P2860
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P2860
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on September 2010
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
@en
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
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type
label
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
@en
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
@nl
prefLabel
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
@en
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
@nl
P2860
P1476
A review of the electrophilic reaction chemistry involved in covalent DNA binding.
@en
P2093
M T D Cronin
P2860
P304
P356
10.3109/10408444.2010.494175
P407
P577
2010-09-01T00:00:00Z