Integrins as therapeutic targets: lessons and opportunities.
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Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectinMolecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular PathologyExtracellular matrix as a contextual determinant of transforming growth factor-β signaling in epithelial-mesenchymal transition and in cancerMolecular imaging of integrin αvβ6 expression in living subjects.Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9.Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug DesignThree-dimensional reconstruction of intact human integrin IIb 3: new implications for activation-dependent ligand bindingA novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesionBiology and structure of leukocyte β 2 integrins and their role in inflammationIntegrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behaviorC-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.Inhibition of α4β1 integrin increases ovarian cancer response to carboplatin.Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules.The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys.Targeting integrin and integrin signaling in treating thrombosis.αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathyEffects of VLA-1 Blockade on Experimental Inflammation in MiceIntegrins as Therapeutic Targets for Respiratory DiseasesRGD-Binding Integrins in Head and Neck Cancers.Fibrosis-dependent mechanisms of hepatocarcinogenesisNitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion.A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical ResectionIntegrins, myofibroblasts, and organ fibrosis.Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2.Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation.The tail of integrin activation.A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinomaReal-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.Integrin α3β1 as a breast cancer targetA missense polymorphism (rs11895564, Ala380Thr) of integrin alpha 6 is associated with the development and progression of papillary thyroid carcinoma in Korean populationThe C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsCilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation.Hepatitis C virus infection: establishment of chronicity and liver disease progressionInsulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB networkProstaglandins in cancer cell adhesion, migration, and invasion
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Integrins as therapeutic targets: lessons and opportunities.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Integrins as therapeutic targets: lessons and opportunities.
@en
Integrins as therapeutic targets: lessons and opportunities.
@nl
type
label
Integrins as therapeutic targets: lessons and opportunities.
@en
Integrins as therapeutic targets: lessons and opportunities.
@nl
prefLabel
Integrins as therapeutic targets: lessons and opportunities.
@en
Integrins as therapeutic targets: lessons and opportunities.
@nl
P356
P1476
Integrins as therapeutic targets: lessons and opportunities.
@en
P2093
Niamh Moran
P2888
P304
P356
10.1038/NRD3266
P577
2010-10-01T00:00:00Z
P5875
P6179
1008531438