New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
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pH sensing and regulation in cancerOvercoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune DysfunctionThe potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in vivoAntioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem CellsRecent developments in targeting carbonic anhydrase IX for cancer therapeuticsMolecular Connections between Cancer Cell Metabolism and the Tumor MicroenvironmentProbing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitorsThe spatial organization of proton and lactate transport in a rat brain tumorExpression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formationThe divergence, actions, roles, and relatives of sodium-coupled bicarbonate transportersCarbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors.Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline.In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.Building on sipuleucel-T for immunologic treatment of castration-resistant prostate cancer.In vivo imaging and quantification of carbonic anhydrase IX expression as an endogenous biomarker of tumor hypoxia.A comparison of the imaging characteristics and microregional distribution of 4 hypoxia PET tracers.Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy.Identification of metal dithiocarbamates as a novel class of antileishmanial agentsZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH.Drug resistance and cellular adaptation to tumor acidic pH microenvironmentProspective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer.Investigational cancer drugs targeting cell metabolism in clinical development.Spatial profiles of markers of glycolysis, mitochondria, and proton pumps in a rat glioma suggest coordinated programming for proliferation.High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapyHypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.Function of carbonic anhydrase IX in glioblastoma multiforme.Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosispHLIP peptide targets nanogold particles to tumorsNeutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level.Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells.Near-Infrared Fluorescence Imaging of Carbonic Anhydrase IX in Athymic Mice Bearing HT-29 Tumor XenograftsMultivoxel ¹H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targetingDIFFERENTIAL PATHWAY DEPENDENCY DISCOVERY ASSOCIATED WITH DRUG RESPONSE ACROSS CANCER CELL LINES.Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression.Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies.Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation.
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New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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New insights into the physiolo ...... se IX in tumour pH regulation.
@en
New insights into the physiolo ...... se IX in tumour pH regulation.
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New insights into the physiolo ...... se IX in tumour pH regulation.
@en
New insights into the physiolo ...... se IX in tumour pH regulation.
@nl
prefLabel
New insights into the physiolo ...... se IX in tumour pH regulation.
@en
New insights into the physiolo ...... se IX in tumour pH regulation.
@nl
P2093
P356
P1433
P1476
New insights into the physiolo ...... se IX in tumour pH regulation.
@en
P2093
A Hulikova
P Swietach
R D Vaughan-Jones
P2888
P304
P356
10.1038/ONC.2010.455
P407
P577
2010-10-04T00:00:00Z