Specialized roles for cysteine cathepsins in health and disease. - Wikidata - awgldk - TriplyDB

Specialized roles for cysteine cathepsins in health and disease.

Specialized roles for cysteine cathepsins in health and disease.

http://www.wikidata.org/entity/Q37797839

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Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes Review of experimental animal models of biliary acute pancreatitis and recent advances in basic research Intracellular killing of bacteria: is Dictyostelium a model macrophage or an alien?Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity Reprogramming of lysosomal gene expression by interleukin-4 and Stat6 CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis.Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition.Isolation and characterization of chicken bile matrix metalloproteinase.High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.Targeted approach to identify genetic loci associated with evolved dioxin tolerance in Atlantic killifish (Fundulus heteroclitus).Regulation of TGF-β1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C.Heterozygous Ile453Val codon mutation in exon 7, homozygous single nucleotide polymorphisms in intron 2 and 5 of cathepsin C are associated with Haim-Munk syndrome Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.Increased serum cathepsin K in patients with coronary artery disease.DNA damage and lamins Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models.CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice Processing of CXCL12 by different osteoblast-secreted cathepsins A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase.Increased expression of cathepsin L: a novel independent prognostic marker of worse outcome in hepatocellular carcinoma patients.Cathepsin B & L are not required for ebola virus replication Adenosine A2A receptor deficiency up-regulates cystatin F expression in white matter lesions induced by chronic cerebral hypoperfusion.Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation.Human epididymis protein 4 and secretory leukocyte protease inhibitor in vaginal fluid: relation to vaginal components and bacterial composition.

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Specialized roles for cysteine cathepsins in health and disease.

http://www.wikidata.org/entity/Q37797839

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2010

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Specialized roles for cysteine cathepsins in health and disease.

@en

Specialized roles for cysteine cathepsins in health and disease.

@nl

type

label

Specialized roles for cysteine cathepsins in health and disease.

@en

Specialized roles for cysteine cathepsins in health and disease.

@nl

prefLabel

Specialized roles for cysteine cathepsins in health and disease.

@en

Specialized roles for cysteine cathepsins in health and disease.

@nl

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Journal of Clinical Investigation

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Specialized roles for cysteine cathepsins in health and disease

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Brian Adair

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Jochen Reiser

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P2860

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

Lysosomal cysteine proteases: facts and opportunities.

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

Secreted cathepsin L generates endostatin from collagen XVIII

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis

Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine

Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

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3421-3431

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scholarly article

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10.1172/JCI42918

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10

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120

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Thomas Reinheckel

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2010-10-01T00:00:00Z

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20921628

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2947230

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