Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
about
DNA polymerase γ and disease: what we have learned from yeastCaenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial ToxicityHIV-1 infection and first line ART induced differential responses in mitochondria from blood lymphocytes and monocytes: the ANRS EP45 "Aging" studyAzidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.Aging and HIV/AIDS: pathogenetic role of therapeutic side effectsTruncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors.Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapyIdentification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.The "fast" and the "slow" modes of mitochondrial DNA degradation.Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γMetal-induced DNA translocation leads to DNA polymerase conformational activation.Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicaseBalancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.Validation of A Point-of-Care Lactate Device For Screening At-Risk Adults Receiving Combination Antiretroviral Therapy In BotswanaAcute pancreatitis in HIV/AIDS patients: an issue of concern.The role of transporters in the toxicity of nucleoside and nucleotide analogs.Ethambutol induced toxic optic neuropathy in HIV positive patients.Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor.Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.HIV-associated sensory neuropathy: risk factors and genetics.The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction.Cardiomyocytes are Protected from Antiretroviral Nucleoside Analog-Induced Mitochondrial Toxicity by Overexpression of PGC-1α.Molecular analysis of mitochondrial compromise in rodent cardiomyocytes exposed long term to nucleoside reverse transcriptase inhibitors (NRTIs).NRTI backbone in HIV treatment: will it remain relevant?From the Cover: Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor.Fibroblast growth factor 23: associations with antiretroviral therapy in patients co-infected with HIV and hepatitis C.Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance.Myoblast mitochondrial respiration is decreased in chronic binge alcohol administered simian immunodeficiency virus-infected antiretroviral-treated rhesus macaques.
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P2860
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 October 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@en
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@nl
type
label
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@en
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@nl
prefLabel
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@en
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@nl
P2860
P1476
Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.
@en
P2093
Christopher A Koczor
William Lewis
P2860
P304
P356
10.1517/17425255.2010.526602
P407
P577
2010-10-07T00:00:00Z