The pathogenic role of Maillard reaction in the aging eye.
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Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallinsAging and age-related diseases of the ocular lens and vitreous bodyRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationAdvanced glycation end products and diabetic complicationsAge-related changes in the kinetics of human lenses: prevention of the cataractSmall changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and diseaseHydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimicsGlycation of nail proteins: from basic biochemical findings to a representative marker for diabetic glycation-associated target organ damageAGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: implications for age-associated fibrosisComprehensive analysis of maillard protein modifications in human lenses: effect of age and cataractUVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation.Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation.Determination of dideoxyosone precursors of AGEs in human lens proteins.Effects of photobleaching on selected advanced glycation end products in the human lens.A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues.Measurement of Lens Autofluorescence Can Distinguish Subjects With Diabetes From Those Without.Intensive diabetes therapy and ocular surgery in type 1 diabetes.The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma.Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging.Simultaneous noninvasive clinical measurement of lens autofluorescence and rayleigh scattering using a fluorescence biomicroscope.Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein ModificationDifferential role of arginine mutations on the structure and functions of α-crystallin.Relationship of cytokines and AGE products in diabetic and non-diabetic patients with cataract.Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αA(ins)-Crystallin Encode Activated ChaperonesNon-enzymatic glycation and glycoxidation protein products in foods and diseases: an interconnected, complex scenario fully open to innovative proteomic studies.Pharmacological therapies for cataract and refractive errors: landscaping niches of ocular drug patenting.Cataract surgery and its complications in diabetic patients.Prevention of protein glycation by natural compounds.Therapeutic potential of α-crystallin.Oxidation as an important factor of protein damage: Implications for Maillard reaction.AGE-RAGE interaction in the TGFβ2-mediated epithelial to mesenchymal transition of human lens epithelial cells.Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches.Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy.Nutraceuticals in prevention of cataract - An evidence based approach.Impact of Non-Enzymatic Glycation in Neurodegenerative Diseases: Role of Natural Products in Prevention.Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro.Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human α-crystallin.Molecular Age-Related Changes in the Anterior Segment of the Eye.Cataract Surgery in Patients with Diabetes: Management Strategies.
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The pathogenic role of Maillard reaction in the aging eye.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 October 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The pathogenic role of Maillard reaction in the aging eye.
@en
The pathogenic role of Maillard reaction in the aging eye.
@nl
type
label
The pathogenic role of Maillard reaction in the aging eye.
@en
The pathogenic role of Maillard reaction in the aging eye.
@nl
prefLabel
The pathogenic role of Maillard reaction in the aging eye.
@en
The pathogenic role of Maillard reaction in the aging eye.
@nl
P2860
P1433
P1476
The pathogenic role of Maillard reaction in the aging eye
@en
P2093
Mikhail Linetsky
Ram H Nagaraj
P2860
P2888
P304
P356
10.1007/S00726-010-0778-X
P50
P577
2010-10-21T00:00:00Z