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Aneugenic effects of epirubicin in somatic and germinal cells of male miceUtility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ CellsThe Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a "Central Dogma" for Toxic Mechanisms?Pericytopathy: oxidative stress and impaired cellular longevity in the pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes.Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress.The effects of a multiflavonoid supplement on vascular and hemodynamic parameters following acute exercise.Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs.Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening.Modeling Reactivity to Biological Macromolecules with a Deep Multitask Network.The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury.Female gender as a susceptibility factor for drug-induced liver injury.Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review.Evaluation of chromosomal instability in diabetic rats treated with naringin.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Human biology-based drug safety evaluation: scientific rationale, current status and future challenges.The Role of Drug Metabolites in the Inhibition of Cytochrome P450 Enzymes.Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A-mediated ortho-benzoquinone metabolite formation and glutathione depletion.Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network.Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma.Impact of dexrazoxane on doxorubicin-induced aneuploidy in somatic and germinal cells of male mice.MerR and ChrR mediate blue light induced photo-oxidative stress response at the transcriptional level in Vibrio choleraeSalubrious effects of dexrazoxane against teniposide-induced DNA damage and programmed cell death in murine marrow cells.Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system.Dexrazoxane Averts Idarubicin-Evoked Genomic Damage by Regulating Gene Expression Profiling Associated With the DNA Damage-Signaling Pathway in BALB/c Mice.Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword.Identification of 4-hydroxynonenal protein targets in rat, mouse and human liver microsomes by two-dimensional liquid chromatography/tandem mass spectrometry.Dexrazoxane mitigates epirubicin-induced genotoxicity in mice bone marrow cells.Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.Effects of fuel components and combustion particle physicochemical properties on toxicological responses of lung cells.Prediction of metabolites of epoxidation reaction in MetaTox.Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Deleterious effects of reactive metabolites.
@en
Deleterious effects of reactive metabolites.
@nl
type
label
Deleterious effects of reactive metabolites.
@en
Deleterious effects of reactive metabolites.
@nl
prefLabel
Deleterious effects of reactive metabolites.
@en
Deleterious effects of reactive metabolites.
@nl
P2860
P356
P1476
Deleterious effects of reactive metabolites.
@en
P2093
Sabry M Attia
P2860
P304
P356
10.4161/OXIM.3.4.13246
P577
2010-07-01T00:00:00Z