about
Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancerStructural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsGene expression profiling of immune-competent human cells exposed to engineered zinc oxide or titanium dioxide nanoparticlesMolecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.Degradation of mutant p53H175 protein by Zn(II) through autophagy.Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophoreDefective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanismStructural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domainMapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cellsZn(II)-curc targets p53 in thyroid cancer cellsUpdates on HIPK2: a resourceful oncosuppressor for clearing cancerGlucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapyAn in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein.A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.Mutant p53 in cancer: new functions and therapeutic opportunities.Pharmacological reactivation of p53 as a strategy to treat cancer.Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores.Zinc and zinc-containing biomolecules in childhood brain tumors.Molecularly targeted therapies for p53-mutant cancers.Identification of interconnected markers for T-cell acute lymphoblastic leukemiap53 reactivation: the link to zinc.Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.
P2860
Q26800059-E6085694-EF7B-43BD-98B4-96A1D855A3DAQ27679121-53F0BF1A-B1C9-4A99-8597-53D7ADC81D27Q28385996-76993771-CFE5-41EF-94EC-BD746EE63F5DQ30668563-58514339-F138-4BF7-8A7B-57746473C968Q33709136-D5F05761-48F9-46DB-96AB-894694CFBDF8Q33798534-2BBCF86C-6F88-4F96-B8F4-DB2AF5F05434Q34185176-C6A41D90-792E-4025-9E96-A2636BF39343Q34619139-B4EC8B91-2E3C-4F65-8803-759C91E4764EQ35051686-45D7069B-DA7F-4C17-918F-5ABE1C327EDDQ35063635-ADCDB50D-7979-4E60-98A6-81C44850B56AQ35531853-AA8D48E1-D7E9-42F9-9054-271B0012C90CQ35986990-899B610A-1E1D-4DA6-970C-4ABBEB1F841BQ36094135-B3D5D284-ACA0-4CED-BC64-AF30C942EE86Q36204714-E648AE97-9945-41A9-8A01-4F21DD7E0095Q36907145-48AA5959-D4EB-411C-B564-B435766EB04DQ37210555-E8843D06-BC2F-4DB5-9A6A-F9B2F11CD9DBQ37364980-76F46731-2CA9-4647-B733-649A0216D4B7Q38197826-56E0DC9B-9994-419C-9457-9D6652C60F32Q38286198-3F6F92AB-9D0C-4079-98F8-6CE5FB0997B6Q38810643-5CE7F6A5-BFBF-4B9F-91D3-25FA88729317Q38957110-8B86F54F-D0CD-4D68-BCD9-A19F985CC439Q39393193-C80260F6-7969-457F-A66F-16CCCBEF9D94Q41969078-34266AF9-6F89-4D39-84FC-64F15ED5A51AQ43092370-9FEAD43E-A0B5-49BE-B741-D5E5B2516BD1Q55471290-90DC8E12-E294-4BCE-B411-74F468771889
P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 May 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The missing zinc: p53 misfolding and cancer.
@en
The missing zinc: p53 misfolding and cancer.
@nl
type
label
The missing zinc: p53 misfolding and cancer.
@en
The missing zinc: p53 misfolding and cancer.
@nl
prefLabel
The missing zinc: p53 misfolding and cancer.
@en
The missing zinc: p53 misfolding and cancer.
@nl
P2860
P356
P1433
P1476
The missing zinc: p53 misfolding and cancer.
@en
P2093
Stewart N Loh
P2860
P304
P356
10.1039/C003915B
P577
2010-05-18T00:00:00Z