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Modulators of the structural dynamics of the retinoid X receptor to reveal receptor functionModulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomersA unique secondary-structure switch controls constitutive gene repression by retinoic acid receptorCharacterization of novel ligands of ERα, Erβ, and PPARγ: the case of halogenated bisphenol A and their conjugated metabolitesStructural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutesINTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphateCombining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallographyFragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activitiesMeeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine.A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding.Structural and functional profiling of environmental ligands for estrogen receptors.Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist.Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptorsSynergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.Separation of retinoid X receptor homo- and heterodimerization functionsThe Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.Androgen and estrogen receptors: potential of crystallography in the fight against cancer.Design of selective nuclear receptor modulators: RAR and RXR as a case study.Inverse agonists and antagonists of retinoid receptors.Retinoic acid receptor modulators: a perspective on recent advances and promises.Modulation of RXR function through ligand design.Retinoid receptors and therapeutic applications of RAR/RXR modulators.Dimerization of nuclear receptors.Nuclear receptor profiling of bisphenol-A and its halogenated analogues.Retinoic acid receptors: structural basis for coregulator interaction and exchange.Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.Glutamic acid 709 substitutions highlight the importance of the interaction between androgen receptor helices H3 and H12 for androgen and antiandrogen actions.A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone.An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.Estrogen-related receptor γ is an in vivo receptor of bisphenol A.RAR-RXR selectivity and biological activity of new retinoic acid analogues with heterocyclic or polycyclic aromatic systems.Pathophysiology of androgen insensitivity syndromes: molecular and structural approaches of natural and engineered androgen receptor mutations at amino acid 743.Mutation of the androgen receptor at amino acid 708 (Gly-->Ala) abolishes partial agonist activity of steroidal antiandrogens.Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation.Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
William Bourguet
@ast
William Bourguet
@en
William Bourguet
@es
William Bourguet
@nl
William Bourguet
@sl
type
label
William Bourguet
@ast
William Bourguet
@en
William Bourguet
@es
William Bourguet
@nl
William Bourguet
@sl
prefLabel
William Bourguet
@ast
William Bourguet
@en
William Bourguet
@es
William Bourguet
@nl
William Bourguet
@sl
P1053
I-5569-2013
P106
P1153
35271198500
P21
P31
P3829
P496
0000-0002-0643-7719