Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.
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The Interplay between Circadian System, Cholesterol Synthesis, and Steroidogenesis Affects Various Aspects of Female ReproductionHidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesisCytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human FibroblastsPolymorphisms of CYP51A1 from cholesterol synthesis: associations with birth weight and maternal lipid levels and impact on CYP51 protein structure.Evaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner.Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylaseThe glypican 3-hosted murine mir717 gene: sequence conservation, seed region polymorphisms and putative targets.Bacterial colonization of host cells in the absence of cholesterol.Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury.Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndromeDisrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling.Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome.Steroidal triterpenes of cholesterol synthesis.The molecular basis of human congenital limb malformations.Simvastatin suppresses head and neck squamous cell carcinoma ex vivo and enhances the cytostatic effects of chemotherapeutics.The mechanism of the effect of U18666a on blocking the activity of 3β-hydroxysterol Δ-24-reductase (DHCR24): molecular dynamics simulation study and free energy analysis.Nonalcoholic Fatty liver disease: focus on lipoprotein and lipid deregulation.
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P2860
Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Defects in cholesterol synthes ...... elopment and safer treatments.
@en
Defects in cholesterol synthes ...... elopment and safer treatments.
@nl
type
label
Defects in cholesterol synthes ...... elopment and safer treatments.
@en
Defects in cholesterol synthes ...... elopment and safer treatments.
@nl
prefLabel
Defects in cholesterol synthes ...... elopment and safer treatments.
@en
Defects in cholesterol synthes ...... elopment and safer treatments.
@nl
P2860
P1476
Defects in cholesterol synthes ...... velopment and safer treatments
@en
P2093
Jim McWhir
Simon Horvat
P2860
P356
10.3109/03602532.2010.540580
P407
P577
2011-02-01T00:00:00Z