Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome.
about
A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma CareNUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase.Copper-zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma.Disulfiram/copper-disulfiram Damages Multiple Protein Degradation and Turnover Pathways and Cytotoxicity is Enhanced by Metformin in Oesophageal Squamous Cell Carcinoma Cell Lines.Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway.High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factorsDisulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models.Cellular redox pathways as a therapeutic target in the treatment of cancer.DNA damage emergency: cellular garbage disposal to the rescue?Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology.Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies.Disulfiram/copper causes redox-related proteotoxicity and concomitant heat shock response in ovarian cancer cells that is augmented by auranofin-mediated thioredoxin inhibition.Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer.Oxidizing to death: disulfiram for cancer cell killing.Comment on 'cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells'.Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways.Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts.
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P2860
Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting malignancies with di ...... angiogenesis, and proteasome.
@en
Targeting malignancies with di ...... angiogenesis, and proteasome.
@nl
type
label
Targeting malignancies with di ...... angiogenesis, and proteasome.
@en
Targeting malignancies with di ...... angiogenesis, and proteasome.
@nl
prefLabel
Targeting malignancies with di ...... angiogenesis, and proteasome.
@en
Targeting malignancies with di ...... angiogenesis, and proteasome.
@nl
P1476
Targeting malignancies with di ...... , angiogenesis, and proteasome
@en
P2093
P304
P356
10.2174/156800911794519806
P50
P577
2011-03-01T00:00:00Z