Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.
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Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cellsMolecules that target nucleophosmin for cancer treatment: an updateThe role of MIZ-1 in MYC-dependent tumorigenesisEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleStructural polymorphism in the N-terminal oligomerization domain of NPM1Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolinA novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclastsPhosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer.Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.Synergic role of nucleophosmin three-helix bundle and a flanking unstructured tail in the interaction with G-quadruplex DNA.Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.Identification of Microprotein-Protein Interactions via APEX TaggingNucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNANucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair.Mutated NPM1 in patients with acute myeloid leukemia in remission and relapse.Nucleolar stress with and without p53.AKT regulates NPM dependent ARF localization and p53mut stability in tumors.A redox mechanism underlying nucleolar stress sensing by nucleophosminDysregulation of RNA polymerase I transcription during disease.Proteasome activity influences UV-mediated subnuclear localization changes of NPM.Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription.Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer.Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma.Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B.The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 bindingInhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesThe expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions.Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.Expression of nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells.Aberrant expression of ALK and EZH2 in Merkel cell carcinomaNucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK SignalingNucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.Nucleolar repression facilitates initiation and maintenance of senescence.14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression.Regulation of host gene expression by HIV-1 TAR microRNAs.Far upstream element binding protein 1: a commander of transcription, translation and beyondThe cell's nucleolus: an emerging target for chemotherapeutic intervention.Identification of chaperones in a MPP+-induced and ATRA/TPA-differentiated SH-SY5Y cell PD model.
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Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 31 January 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Nucleophosmin and its complex ...... get in hematological diseases.
@en
Nucleophosmin and its complex ...... get in hematological diseases.
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type
label
Nucleophosmin and its complex ...... get in hematological diseases.
@en
Nucleophosmin and its complex ...... get in hematological diseases.
@nl
prefLabel
Nucleophosmin and its complex ...... get in hematological diseases.
@en
Nucleophosmin and its complex ...... get in hematological diseases.
@nl
P356
P1433
P1476
Nucleophosmin and its complex ...... rget in hematological diseases
@en
P2093
P G Pelicci
P2888
P304
P356
10.1038/ONC.2010.646
P407
P577
2011-01-31T00:00:00Z