Genetic and molecular basis of inflammasome-mediated disease.
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Making sense of the cytokine storm: a conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromesThe inflammasome: an emerging therapeutic oncotarget for cancer preventionCalcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasomeThe PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory DiseaseCARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanismsNLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammationMultiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.Hyaluronan activation of the Nlrp3 inflammasome contributes to the development of airway hyperresponsiveness.NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasomeBench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspectiveRoles of heat-shock protein 70 in protecting against intestinal mucosal damageESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivoTreating inflammation by blocking interleukin-1 in humans.Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function.Cryopyrin-associated periodic syndromes: diagnosis and management.Caspase-1: is IL-1 just the tip of the ICEberg?The genetics of innate immunity sensors and human disease.Licensing Adaptive Immunity by NOD-Like Receptors.NLRC5 mediates cytokine secretion in RAW264.7 macrophages and modulated by the JAK2/STAT3 pathway.Real-life effectiveness of canakinumab in cryopyrin-associated periodic syndrome.Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiationThe deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.IL-1β suppresses TGF-β-mediated myofibroblast differentiation in cardiac fibroblasts.Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases.COPs and POPs Patrol Inflammasome Activation.Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome.
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Genetic and molecular basis of inflammasome-mediated disease.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 04 February 2011
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vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genetic and molecular basis of inflammasome-mediated disease.
@en
Genetic and molecular basis of inflammasome-mediated disease.
@nl
type
label
Genetic and molecular basis of inflammasome-mediated disease.
@en
Genetic and molecular basis of inflammasome-mediated disease.
@nl
prefLabel
Genetic and molecular basis of inflammasome-mediated disease.
@en
Genetic and molecular basis of inflammasome-mediated disease.
@nl
P2860
P356
P1476
Genetic and molecular basis of inflammasome-mediated disease.
@en
P2093
Hal M Hoffman
Susannah D Brydges
P2860
P304
10889-10896
P356
10.1074/JBC.R110.135491
P407
P577
2011-02-04T00:00:00Z