about
Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesionsToll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formationThe microtubule regulator stathmin is an endogenous protein agonist for TLR3.Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial.Human glial cell culture models of inflammation in the central nervous system.Stress proteins in CNS inflammation.Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies.The link between small heat shock proteins and the immune system.Oligodendrocyte-microglia cross-talk in the central nervous system.Inflammation in neurodegenerative diseases--an update.Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles.Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE.Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.Multiple sclerosis: modelling the future. The Multiple Sclerosis Society of Great Britain and Northern Ireland Conference: Frontiers in Science and Patient Care Disease Management.Multiple sclerosis: an altered immune response or an altered stress response?Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli.T- and B-cell nonresponsiveness to self-alphaB-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis.Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin.The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells.Multiple sclerosis: variations on a theme.Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC.Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.Visualization of proteases within a complex sample following their selective retention on immobilized bacitracin, a peptide antibiotic.Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.T cells discriminate between differentially phosphorylated forms of alphaB-crystallin, a major central nervous system myelin antigen.Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS.AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic.Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire.Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators.Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus.Tolerization of an established alphaB-crystallin-reactive T-cell response by intravenous antigen.Selective association of multiple sclerosis with infectious mononucleosis.Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A.Late rather than early responses of human dendritic cells highlight selective induction of cytokines, chemokines and growth factors by probiotic bacteria.PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesionsProtein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitisIsolation and characterization of mutants of Aspergillus niger deficient in extracellular proteasesExpression of αB-crystallin in glia cells during lesional development in multiple sclerosisPurification of the stress protein αB-crystallin and its differentially phosphorylated forms
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description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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type
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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Johannes M van Noort
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P106
P1153
7006905499
P21
P31
P496
0000-0002-9060-5921