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The Use of 1α,25-Dihydroxyvitamin D₃ as an Anticancer AgentIs lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?Biological evaluation of new vitamin D2 analoguesUp-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapyThe Cytokine Flt3-Ligand in Normal and Malignant HematopoiesisExpression of epithelial membrane and 3-fucosyl-N-acetyllactosamine antigens in cervix uteri with particular reference to adenocarcinoma in situThe prospects of retinoids in the treatment of prostate cancer.The development and growth of tissues derived from cranial neural crest and primitive mesoderm is dependent on the ligation status of retinoic acid receptor γ: evidence that retinoic acid receptor γ functions to maintain stem/progenitor cells in theCell differentiation and proliferation--simultaneous but independent?Vitamin D and hematopoiesis.Defective erythropoiesis in myelodysplastic syndromes.Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells.The versatility of haematopoietic stem cells: implications for leukaemia.Models of haemopoiesis.Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia.The versatile landscape of haematopoiesis: are leukaemia stem cells as versatile?Versatility of stem and progenitor cells and the instructive actions of cytokines on hematopoiesis.Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D₂ as Potential Anti-Leukemic Agents.An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium.Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D₂ Against Human Malignant Melanoma Cell Lines.Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Transferrin receptors in human tissues: their distribution and possible clinical relevance.The role of protein phosphorylation in the control of cell growth and differentiation.Presence of 3-fucosyl-N-acetyllactosamine shown by monoclonal antibody AGF 4.48 in Reed-Sternberg cellsThe development of cell lineages: a sequential model.Inositol lipids and phosphates in erythrocytes and HL60 cells.Stochastic or ordered lineage commitment during hemopoiesis?1Alpha,25-dihydroxyvitamin D3-mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc-mediated activation of the RAS/RAF/ERK-MAP kinase signalling pathway.1alpha,25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms.A retinoid-related molecule that does not bind to classical retinoid receptors potently induces apoptosis in human prostate cancer cells through rapid caspase activation.Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells.Regulation of vitamin D receptor expression by retinoic acid receptor alpha in acute myeloid leukemia cells.Stathmin is expressed by the proliferating hepatocytes during liver regeneration.Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics.Convergent synthesis of double point modified analogs of 1α,25-dihydroxyvitamin D2 for biological evaluation.Triiodothyronine blocks potentiation of HL60 monocyte differentiation by anti-inflammatory agents and by steroids and induces apoptosis of all-trans retinoic acid "primed" cells.Particular combinations of signals, by retinoic acid and 1 alpha, 25 dihydroxyvitamin D3, promote apoptosis of HL60 cells.Persistent growth of BALB/C mouse plasmacytoma and human myeloma cell lines in the presence of phorbol myristate acetate is associated with continued expression of Lap18 (stathmin).Near neighbour analysis of variant cell lines derived from the promyeloid cell line HL60
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hulumtues
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onderzoeker
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researcher
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հետազոտող
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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Geoffrey Brown
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P106
P21
P31
P496
0000-0003-0821-0275