about
A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesityUncoupling proteins: current status and therapeutic prospectsAs the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressorUCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutralityBrown adipose tissue: function and physiological significanceUnexpected evidence for active brown adipose tissue in adult humansUCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity.β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway.Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle.UCP1: the original uncoupling protein--and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice.Adipose tissue pathways involved in weight loss of cancer cachexiaGene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity.Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adThe expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue.Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice.Genetic and functional characterization of clonally derived adult human brown adipocytes.Thermogenesis challenges the adipostat hypothesis for body-weight control.Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis.Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.PPARgamma in the control of brown adipocyte differentiation.Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondriaHuman mediastinal adipose tissue displays certain characteristics of brown fat.Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.The changed metabolic world with human brown adipose tissue: therapeutic visions.Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).Nonshivering thermogenesis and its adequate measurement in metabolic studies.Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?Brown adipose tissue as an anti-obesity tissue in humans.Leptin Raises Defended Body Temperature without Activating Thermogenesis.Single Case Method in Psychology: How to Improve as a Possible Methodology in Quantitative Research.Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.The β3-adrenergic receptor is dispensable for browning of adipose tissues.UCP1 in adipose tissues: two steps to full browning.A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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Jan Nedergaard
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P106
P1153
7007060787
P21
P2798
P31
P496
0000-0003-2070-1587