Tpl2 kinase signal transduction in inflammation and cancer.
about
The dynamic nature of the kinomeTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerIKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomasAltered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout miceCot/tpl2 participates in the activation of macrophages by adiponectin.TPL2 kinase regulates the inflammatory milieu of the myeloma nicheTPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling.Macrophages in multiple myeloma: emerging concepts and therapeutic implications.MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury.Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple MyelomaCot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophagesAberrant expression of COT is related to recurrence of papillary thyroid cancer.'Metabolically healthy obesity': origins and implications.TPL2 kinase is a suppressor of lung carcinogenesisSterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma.Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virusThe role of tumor progression locus 2 protein kinase in glial inflammatory response.ERK5 and its role in tumour development.IκB kinase regulation of the TPL-2/ERK MAPK pathway.A preliminary study on methylphenidate-regulated gene expression in lymphoblastoid cells of ADHD patients.Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs.Physical and functional interaction of the TPL2 kinase with nucleophosmin.Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemiaThe Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.TPL2-NPM-p53 pathway monitors nucleolar stress.Immunoregulatory roles of versican proteolysis in the myeloma microenvironment.Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in miceTPL2 is a key regulator of intestinal inflammation in C. difficile infection.The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network
P2860
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P2860
Tpl2 kinase signal transduction in inflammation and cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 05 March 2011
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tpl2 kinase signal transduction in inflammation and cancer.
@en
Tpl2 kinase signal transduction in inflammation and cancer.
@nl
type
label
Tpl2 kinase signal transduction in inflammation and cancer.
@en
Tpl2 kinase signal transduction in inflammation and cancer.
@nl
prefLabel
Tpl2 kinase signal transduction in inflammation and cancer.
@en
Tpl2 kinase signal transduction in inflammation and cancer.
@nl
P50
P1433
P1476
Tpl2 kinase signal transduction in inflammation and cancer
@en
P2093
Kalliopi Gkouskou
P356
10.1016/J.CANLET.2011.02.004
P407
P577
2011-03-05T00:00:00Z