Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic propertiesMacrocyclic protease inhibitors with reduced peptide characterStructural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL ProteaseSynthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclizationRing-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery.Large ring-forming alkylations provide facile access to composite macrocyclesEssential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.Redox-triggered self-assembly of gadolinium-based MRI probes for sensing reducing environmentBuild/couple/pair strategy for the synthesis of stereochemically diverse macrolactams via head-to-tail cyclization.Minimal fluorous tagging strategy that enables the synthesis of the complete stereoisomer library of SCH725674 macrolactonesA two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.Global analysis of peptide cyclization efficiency.Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers.Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Macrocyclic drugs and synthetic methodologies toward macrocyclesA strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.Peptidomimetics via modifications of amino acids and peptide bonds.How proteins bind macrocycles.Comprehensive analysis of loops at protein-protein interfaces for macrocycle design.Peptides come round: using SICLOPPS libraries for early stage drug discovery.A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffoldsRibosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsTwisted amide electrophiles enable cyclic peptide sequencing.New Frontiers in DruggabilityState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Hitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?Phage-displayed macrocyclic glycopeptide libraries.Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Harnessing C-H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones.Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli.Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivativesSynthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection.Butelase-Mediated Macrocyclization of d-Amino-Acid-Containing Peptides.Strained cyclophane macrocycles: impact of progressive ring size reduction on synthesis and structureAdvances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.
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Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 March 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@en
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@nl
type
label
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@en
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@nl
prefLabel
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@en
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@nl
P356
P1476
Macrocycles are great cycles: ...... macrocycles in drug discovery.
@en
P2093
Eric Marsault
Mark L Peterson
P304
P356
10.1021/JM1012374
P407
P577
2011-03-07T00:00:00Z