Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.
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Acid-sensing ion channels in pain and disease.Structure and activity of the acid-sensing ion channelsASICs as therapeutic targets for migraineStructural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexesX-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective ChannelA single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC)Physiological and pathological functions of acid-sensing ion channels in the central nervous system.The Concise Guide to PHARMACOLOGY 2013/14: ion channelsLocalization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.Acid-sensing ion channels in mouse olfactory bulb M/T neurons.Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometrySelective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury.Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs.Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.Extracellular pH modulates GABAergic neurotransmission in rat hypothalamus.The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking.Physiological carbon dioxide, bicarbonate, and pH sensingIonotropic receptors and ion channels in ischemic neuronal death and dysfunction.Acid-sensing ion channels: trafficking and synaptic function.The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke interventionMolecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death.Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injuryIon selectivity in the selectivity filters of acid-sensing ion channels.Spider-venom peptides as therapeutics.Acid-sensing ion channels: potential therapeutic targets for neurologic diseases.Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition.Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injuryInhibition of human acid-sensing ion channel 1b by zincMolecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expressionOptogenetic approaches addressing extracellular modulation of neural excitability.Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice.Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain.ASIC1a activation enhances inhibition in the basolateral amygdala and reduces anxiety.Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a).Rethinking Heart Failure.Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential.Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels.Endosomal pH in neuronal signaling and synaptic transmission: role of Na(+)/H(+) exchanger NHE5.Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?
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P2860
Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 March 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structure, function, and pharm ...... nels (ASICs): focus on ASIC1a.
@en
Structure, function, and pharm ...... nels (ASICs): focus on ASIC1a.
@nl
type
label
Structure, function, and pharm ...... nels (ASICs): focus on ASIC1a.
@en
Structure, function, and pharm ...... nels (ASICs): focus on ASIC1a.
@nl
prefLabel
Structure, function, and pharm ...... nels (ASICs): focus on ASIC1a.
@en
Structure, function, and pharm ...... nels (ASICs): focus on ASIC1a.
@nl
P2860
P1476
Structure, function, and pharm ...... nnels (ASICs): focus on ASIC1a
@en
P2093
Stefan Gründer
Xuanmao Chen
P2860
P577
2010-03-18T00:00:00Z