Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
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Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueKCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targetingPhotoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs).Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.Protein-polymer conjugation via ligand affinity and photoactivation of glutathione S-transferaseDesign and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling.Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach.Photoaffinity labeling in target- and binding-site identification6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative.Efficient Covalent Bond Formation in Gas-Phase Peptide-Peptide Ion Complexes with the Photoleucine Stapler.Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein InteractionPhotolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator.Protein organic chemistry and applications for labeling and engineering in live-cell systems.Recent advances in target characterization and identification by photoaffinity probes.Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!Turning the spotlight on protein-lipid interactions in cells.A diazirine-based photoaffinity probe for facile and efficient aptamer-protein covalent conjugation.Development of Photoactivatable Allosteric Modulators for the Chemokine Receptor CXCR3.Affinity purification in target identification: the specificity challenge.Amino Acid Insertion Frequencies Arising from Photoproducts Generated Using Aliphatic Diazirines.Target identification of natural products and bioactive compounds using affinity-based probes.Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors.Cell-based proteome profiling using an affinity-based probe (AfBP) derived from 3-deazaneplanocin A (DzNep).Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon.Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes.The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila.Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.Electron transfer dissociation of photolabeled peptides. Backbone cleavages compete with diazirine ring rearrangements.Photoactivation of (p-methoxyphenyl)(trifluoromethyl)diazirine in the presence of phenolic reaction partners.A trifunctional cyclooctyne for modifying azide-labeled biomolecules with photocrosslinking and affinity tags.Electron transfer reduction of the diazirine ring in gas-phase peptide ions. On the peculiar loss of [NH4O] from photoleucine.Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.Simple Light-Triggered Fluorescent Labeling of Silica Nanoparticles for Cellular Imaging Applications.Base-Mediated One-Pot Synthesis of Aliphatic Diazirines for Photoaffinity Labeling.Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences.
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Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 05 April 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@en
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@nl
type
label
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@en
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@nl
prefLabel
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@en
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@nl
P356
P1433
P1476
Aliphatic diazirines as photoaffinity probes for proteins: recent developments.
@en
P2093
Joydip Das
P304
P356
10.1021/CR1002722
P577
2011-04-05T00:00:00Z