The multifaceted roles of USP7: new therapeutic opportunities.
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HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulatorUV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repairDUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsThe Ubiquitination of NF-κB Subunits in the Control of TranscriptionRole of Deubiquitinating Enzymes in DNA RepairDeubiquitinating enzymes as oncotargetsA Role for USP7 in DNA ReplicationModulation of the p53/MDM2 interplay by HAUSP inhibitorsThe shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7The role of UBL domains in ubiquitin-specific proteasesUVSSA and USP7, a new couple in transcription-coupled DNA repairModulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African TrypanosomesUSP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental DisorderDeubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathwayUSP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets.WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathwayDeubiquitylation of deubiquitylasesUsp7 protects genomic stability by regulating Bub3.Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation.RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions.Development of inhibitors in the ubiquitination cascade.DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilizationUSP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma.The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments.Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Flickin' the ubiquitin switch: the role of H2B ubiquitylation in development.Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities.FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian ClockThe Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancerSupervillin-mediated suppression of p53 protein enhances cell survival.
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The multifaceted roles of USP7: new therapeutic opportunities.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on June 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The multifaceted roles of USP7: new therapeutic opportunities.
@en
The multifaceted roles of USP7: new therapeutic opportunities.
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type
label
The multifaceted roles of USP7: new therapeutic opportunities.
@en
The multifaceted roles of USP7: new therapeutic opportunities.
@nl
prefLabel
The multifaceted roles of USP7: new therapeutic opportunities.
@en
The multifaceted roles of USP7: new therapeutic opportunities.
@nl
P2860
P1476
The multifaceted roles of USP7: new therapeutic opportunities.
@en
P2093
Benjamin Nicholson
K G Suresh Kumar
P2860
P2888
P356
10.1007/S12013-011-9185-5
P577
2011-06-01T00:00:00Z