Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
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Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's DiseaseFK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Lysosome and calcium dysregulation in Alzheimer's disease: partners in crimeDisturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro.Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.Bilayer measurement of endoplasmic reticulum Ca2+ channels.Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.β amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease miceβ-Secretase: its biology as a therapeutic target in diseasesMembrane trafficking in neuronal maintenance and degeneration.Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease.Early onset Alzheimer's disease and oxidative stress.Autophagic/lysosomal dysfunction in Alzheimer's disease.Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease.The very many faces of presenilins and the γ-secretase complex.Endoplasmic reticulum stress as a novel neuronal mediator in Alzheimer's disease.Dantrolene, a treatment for Alzheimer disease?Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression.Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease.Calcium's role as nuanced modulator of cellular physiology in the brain.Emerging pathways driving early synaptic pathology in Alzheimer's disease.Amyloid-beta disrupts calcium and redox homeostasis in brain endothelial cells.ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.Presenilin adopts the ClC channel foldCRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice: involvement of adjusting neurotransmitters and their metabolite changes in the brain.Calsenilin contributes to neuronal cell death in ischemic stroke.Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1.
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Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 June 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
@en
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
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type
label
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
@en
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
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prefLabel
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
@en
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
@nl
P2860
P1433
P1476
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
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P2093
Charlene Supnet
Ilya Bezprozvanny
P2860
P304
P356
10.1016/J.CECA.2011.05.013
P577
2011-06-12T00:00:00Z