New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
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FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Role of apoptosis in diseaseMitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell deathStem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death.Age-Dependent Modifications of AMPA Receptor Subunit Expression Levels and Related Cognitive Effects in 3xTg-AD Mice.Extremely low-frequency magnetic exposure appears to have no effect on pathogenesis of Alzheimer's disease in aluminum-overloaded ratZinc deficiency is common in several psychiatric disorders.Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma.Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.The neurophysiology and pathology of brain zinc.Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.Early and sustained altered expression of aging-related genes in young 3xTg-AD mice.Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease.NRF2 and p53: Januses in cancer?Zinc and its effects on oxidative stress in Alzheimer's disease.The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.Supplementation with zinc in rats enhances memory and reverses an age-dependent increase in plasma copper.Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease.Ca(2+) enhances Aβ polymerization rate and fibrillar stability in a dynamic manner.Characterisation of element profile changes induced by long-term dietary supplementation of zinc in the brain and cerebellum of 3xTg-AD mice by alternated cool and normal plasma ICP-MS.Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation.Neurotoxicity of Zinc.Characterizing serum metabolic alterations of Alzheimer's disease and intervention of Shengmai-San by ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.Influence of APOE and RNF219 on Behavioral and Cognitive Features of Female Patients Affected by Mild Cognitive Impairment or Alzheimer's Disease.The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.
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P2860
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 June 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
@en
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
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type
label
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
@en
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
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prefLabel
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
@en
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
@nl
P2093
P2860
P921
P356
P1476
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.
@en
P2093
A Pensalfini
V Frazzini
P2860
P356
10.1038/CDDIS.2011.57
P5008
P577
2011-06-23T00:00:00Z