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Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine groupCharacterisation of the gene encoding type II DNA topoisomerase from Leishmania donovani: a key molecular target in antileishmanial therapyA terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning.Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and LeishmaniaCloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors.Immunohistochemical study of DNA topoisomerase II in human gastric disordersNovel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme.Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.Mechanisms of resistance to combinations of vincristine, etoposide and doxorubicin in Chinese hamster ovary cells.Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin.Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNAKinetoplast maxicircle DNA replication in Crithidia fasciculata and Trypanosoma brucei.The gene encoding topoisomerase II from Plasmodium falciparumIntegration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide).Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer.An insight into the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani.CP-115,953 stimulates cytokine production by lymphocytes.Hydropathic analysis of the free energy differences in anthracycline antibiotic binding to DNAStructure-activity relationships and modes of action of 9-anilinoacridines against chloroquine-resistant Plasmodium falciparum in vitro.Induction of apoptosis in human cancer cell lines by the novel anthracenyl-amino acid topoisomerase I inhibitor NU/ICRF 505.Formation of adriamycin--DNA adducts in vitro.Multilevel therapeutic targeting by topoisomerase inhibitors.Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
DNA topoisomerases as anticancer drug targets.
@en
DNA topoisomerases as anticancer drug targets.
@nl
type
label
DNA topoisomerases as anticancer drug targets.
@en
DNA topoisomerases as anticancer drug targets.
@nl
prefLabel
DNA topoisomerases as anticancer drug targets.
@en
DNA topoisomerases as anticancer drug targets.
@nl
P2093
P1476
DNA topoisomerases as anticancer drug targets.
@en
P2093
P304
P577
1990-01-01T00:00:00Z