Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase.
about
SRChing for the substrates of Src.Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporterTargeting the C-terminal focal adhesion kinase scaffold in pancreatic cancerPTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study.Defective apical extrusion signaling contributes to aggressive tumor hallmarksTumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer.Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogsPTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis.Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cellsFocal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells.FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancerThe FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.Targeting focal adhesion kinase in fibrotic diseases.Integrins and integrin-related proteins in cardiac fibrosis.A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.Prognostic Significance of Focal Adhesion Kinase in Node-Negative Breast Cancer.The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer.Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer.
P2860
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P2860
Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Clinical importance and potent ...... tors of focal adhesion kinase.
@en
Clinical importance and potent ...... tors of focal adhesion kinase.
@nl
type
label
Clinical importance and potent ...... tors of focal adhesion kinase.
@en
Clinical importance and potent ...... tors of focal adhesion kinase.
@nl
prefLabel
Clinical importance and potent ...... tors of focal adhesion kinase.
@en
Clinical importance and potent ...... tors of focal adhesion kinase.
@nl
P1476
Clinical importance and potent ...... tors of focal adhesion kinase.
@en
P2093
Alexander Schultze
Walter Fiedler
P304
P356
10.2174/187152011796817727
P577
2011-09-01T00:00:00Z