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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processingAbnormal kalirin signaling in neuropsychiatric disorders.Trafficking regulation of proteins in Alzheimer's diseaseThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationNeural circuit rewiring: insights from DD synapse remodelingApolipoprotein E and Alzheimer disease: risk, mechanisms and therapyHsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairmentEffect of edge pruning on structural controllability and observability of complex networksThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.Neuronal clearance of amyloid-β by endocytic receptor LRP1.Fragile X tremor ataxia syndrome and white matter dementia.VSNL1 Co-Expression Networks in Aging Include Calcium Signaling, Synaptic Plasticity, and Alzheimer's Disease PathwaysBrain plasticity-based therapeuticsDevelopmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.Studying synapses in human brain with array tomography and electron microscopyReduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseAltered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathologyModel Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain.Modeling amyloid-beta as homogeneous dodecamers and in complex with cellular prion protein.Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model.Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons.Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonistAmyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapseApolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-βThe evolving role of dendritic spines and memory: Interaction(s) with estradiolNeuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.Mathematical model on Alzheimer's diseaseOrchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulationβ-Amyloid oligomers in aging and Alzheimer's disease.Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy eldersTranscriptional regulation and its misregulation in Alzheimer's disease.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Alzheimer's disease: synapses gone cold.
@en
Alzheimer's disease: synapses gone cold.
@nl
type
label
Alzheimer's disease: synapses gone cold.
@en
Alzheimer's disease: synapses gone cold.
@nl
prefLabel
Alzheimer's disease: synapses gone cold.
@en
Alzheimer's disease: synapses gone cold.
@nl
P2860
P356
P1476
Alzheimer's disease: synapses gone cold.
@en
P2093
Robert M Koffie
P2860
P2888
P356
10.1186/1750-1326-6-63
P577
2011-08-26T00:00:00Z
P5875
P6179
1001006189