mTOR: A pathogenic signaling pathway in developmental brain malformations.
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mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosisMammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain FunctionRELN Mutations in Autism Spectrum DisorderEpilepsy related to developmental tumors and malformations of cortical developmentThe search for circulating epilepsy biomarkersFinding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic targetConvulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement.Diagnostic methods and treatment options for focal cortical dysplasiaKICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndromeRapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorderHuman papillomavirus proteins are found in peripheral blood and semen Cd20+ and Cd56+ cells during HPV-16 semen infectionDe novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 Neurological AbnormalitiesMolecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder.Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia.A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors.Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction.Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies.Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycansmTOR signaling in epilepsy: insights from malformations of cortical developmentHemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR.SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis ComplexMultiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmissionFrom Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease.Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphologyRecessive Inactivating Mutations in TBCK, Encoding a Rab GTPase-Activating Protein, Cause Severe Infantile Syndromic Encephalopathy.Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia.Group II mGlu receptor antagonist LY341495 enhances the antidepressant-like effects of ketamine in the forced swim test in ratsNeuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury.Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.Is focal cortical dysplasia an infectious disease?Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration.A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials.Genetics of tuberous sclerosis complex: implications for clinical practiceGenetic testing for autism spectrum disorders.mTOR signaling in neural stem cells: from basic biology to disease.
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P2860
mTOR: A pathogenic signaling pathway in developmental brain malformations.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
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name
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@en
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@nl
type
label
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@en
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@nl
prefLabel
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@en
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@nl
P1476
mTOR: A pathogenic signaling pathway in developmental brain malformations.
@en
P2093
Peter B Crino
P304
P356
10.1016/J.MOLMED.2011.07.008
P577
2011-09-02T00:00:00Z