Venoms as a platform for human drugs: translating toxins into therapeutics.
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The lethal toxin from Australian funnel-web spiders is encoded by an intronless geneEngineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptorsNeuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disordersDiscovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide ToxinsVenoms of Heteropteran Insects: A Treasure Trove of Diverse Pharmacological ToolkitsCabinet of Curiosities: Venom Systems and Their Ecological Function in Mammals, with a Focus on PrimatesGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsStructure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activityNemertean toxin genes revealed through transcriptome sequencing.A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating DomainSample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegataSolution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschiA minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulinLatarcins: versatile spider venom peptidesRecombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockersDiversity of conotoxin gene superfamilies in the venomous snail, Conus victoriaePlectreurys tristis venome: A proteomic and transcriptomic analysisClawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (centipedes)Tracing monotreme venom evolution in the genomics eraThe first venomous crustacean revealed by transcriptomics and functional morphology: remipede venom glands express a unique toxin cocktail dominated by enzymes and a neurotoxinHigh-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discoveryAnticonvulsant Effects of Fractions Isolated from Dinoponera quadriceps (Kempt) Ant Venom (Formicidae: Ponerinae)Venom Profiling of a Population of the Theraphosid Spider Phlogius crassipes Reveals Continuous Ontogenetic Changes from Juveniles through AdulthoodFrom Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders.The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.Venomous and poisonous Australian animals of veterinary importance: a rich source of novel therapeutics.Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.A Polychaete's powerful punch: venom gland transcriptomics of Glycera reveals a complex cocktail of toxin homologsCobra cytotoxins: structural organization and antibacterial activity.Elapid snake venom analyses show the specificity of the peptide composition at the level of genera Naja and NotechisHigh throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli.Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula.Pathogen-inspired drug delivery to the central nervous system.Comprehensive analysis of the venom gland transcriptome of the spider Dolomedes fimbriatusScreening for voltage-gated sodium channel interacting peptides.Androcin, a novel type of cysteine-rich venom peptide from Androctonus bicolor, induces akinesia and anxiety-like symptoms in mice.Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint
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P2860
Venoms as a platform for human drugs: translating toxins into therapeutics.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
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name
Venoms as a platform for human drugs: translating toxins into therapeutics.
@en
Venoms as a platform for human drugs: translating toxins into therapeutics.
@nl
type
label
Venoms as a platform for human drugs: translating toxins into therapeutics.
@en
Venoms as a platform for human drugs: translating toxins into therapeutics.
@nl
prefLabel
Venoms as a platform for human drugs: translating toxins into therapeutics.
@en
Venoms as a platform for human drugs: translating toxins into therapeutics.
@nl
P2860
P1476
Venoms as a platform for human drugs: translating toxins into therapeutics.
@en
P2860
P304
P356
10.1517/14712598.2011.621940
P407
P50
P577
2011-09-23T00:00:00Z