Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.

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Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease The Wonders of Phosphodiesterase-5 Inhibitors: A Majestic History Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012 Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity Targeting the sarcomere to correct muscle function Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.An atypical phosphodiesterase capable of degrading haloalkyl phosphate diesters from Sphingobium sp. strain TCM1.Advances in targeting cyclic nucleotide phosphodiesterases Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease.Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model.Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder.Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1.cAMP and mitochondria.Clinical and molecular genetics of the phosphodiesterases (PDEs).Recent insights in the paracrine modulation of cardiomyocyte contractility by cardiac endothelial cells.Quinoxaline derivatives: a patent review (2006--present).Phosphodiesterase 10A inhibitors: a 2009 - 2012 patent update.A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.Phosphodiesterase inhibitors for chronic obstructive pulmonary disease: what does the future hold?Phosphodiesterase 10A inhibitors: analysis of US/EP patents granted since 2012.Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness.PDE5 expression in human thyroid tumors and effects of PDE5 inhibitors on growth and migration of cancer cells.Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216.Effects of cyclic nucleotide phosphodiesterases (PDEs) on mitochondrial skeletal muscle functions.Can Cyclic Nucleotide Phosphodiesterase Inhibitors Be Drugs for Parkinson's Disease?Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder.Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells.SFPQ, a multifunctional nuclear protein, regulates the transcription of PDE3A Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria.

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P2860

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.

Item

http://www.wikidata.org/entity/Q37947681

description

article científic

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article scientifique

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articol științific

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articolo scientifico

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artigo científico

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artigo científico

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artigo científico

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artikel ilmiah

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artikull shkencor

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artículo científico

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name

Cyclic nucleotide phosphodiest ...... ture therapeutic developments.

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Cyclic nucleotide phosphodiesterase

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type

Item

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Cyclic nucleotide phosphodiest ...... ture therapeutic developments.

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Cyclic nucleotide phosphodiesterase

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Cyclic nucleotide phosphodiest ...... ture therapeutic developments.

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Cyclic nucleotide phosphodiesterase

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P1476

Cyclic nucleotide phosphodiest ...... ture therapeutic developments.

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P2093

Claire Lugnier

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Thérèse Keravis

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression

Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase

Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

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1288-1305

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scholarly article

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10.1111/J.1476-5381.2011.01729.X

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English

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165

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2012-03-01T00:00:00Z

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22014080

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P932

3372715

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Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.

about

P2860

P2860

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P932