Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.
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Nucleoside inhibitors of tick-borne encephalitis virusPotent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance ProfilingSynthesis of nucleoside phosphate and phosphonate prodrugsProdrugs of phosphonates and phosphates: crossing the membrane barrierStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNADiscovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.Discovery of N -[4-[6- tert -Butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H -pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B PolymeraseThe Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug DesignInhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding InteractionsDiscovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and DockingAnalysis of Ribonucleotide 5’ -Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-dependent RNA Polymerase Using Non-Radioactive Polymerase AssaysPreclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.A cutting-edge view on the current state of antiviral drug development.New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors.Brønsted acid catalyzed phosphoramidic acid additions to alkenes: diastereo- and enantioselective halogenative cyclizations for the synthesis of C- and P-chiral phosphoramidatesOne-electron oxidation of gemcitabine and analogs: mechanism of formation of C3' and C2' sugar radicals.Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline.Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug designCurrent tools for norovirus drug discoveryAnti-norovirus therapeutics: a patent review (2010-2015).The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.Sensitivity of the polymerase of vesicular stomatitis virus to 2' substitutions in the template and nucleotide triphosphate during initiation and elongation.New treatments for chronic hepatitis C: an overview for paediatricians.Palladium-catalyzed modification of unprotected nucleosides, nucleotides, and oligonucleotides.Beclabuvir for the treatment of hepatitis C.Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights.Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues.Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.Synthesis and Anti-HCV Activity of 4-Hydroxyamino α-Pyranone Carboxamide Analogues.Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future.Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness.Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates.
P2860
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P2860
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@en
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@nl
type
label
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@en
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@nl
prefLabel
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@en
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@nl
P2093
P356
P1476
Nucleoside, nucleotide, and no ...... RNA-dependent RNA-polymerase.
@en
P2093
Bruce S Ross
Michael J Sofia
Phillip A Furman
Ralph T Mosley
Wonsuk Chang
P304
P356
10.1021/JM201384J
P407
P577
2012-01-23T00:00:00Z