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Antimicrobial Drugs in Fighting against Antimicrobial ResistanceBreaking the Spell: Combating Multidrug Resistant 'Superbugs'Can we prevent antimicrobial resistance by using antimicrobials better?Methicillin-resistant Staphylococcus aureus therapy: past, present, and futureStructural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesisClinical management of infections caused by multidrug-resistant EnterobacteriaceaeAntibiotics and bacterial resistance in the 21st century.Investigational antimicrobial agents of 2013.Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase.Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201AThe Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GSK1322322 in Healthy Volunteers.Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.Comparison of plasma, epithelial lining fluid, and alveolar macrophage concentrations of solithromycin (CEM-101) in healthy adult subjects.Pipeline of Known Chemical Classes of Antibiotics.Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: current and emerging therapeutic approaches.New antibiotic agents in the pipeline and how they can help overcome microbial resistance.Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance.Penetration of GSK1322322 into epithelial lining fluid and alveolar macrophages as determined by bronchoalveolar lavage3D-QSAR and molecular docking for the discovery of ketolide derivatives.Developing new antibacterials through natural product research.Current strategies for the treatment of complicated intraabdominal infections.New antibiotics for bad bugs: where are we?Eravacycline for the treatment of intra-abdominal infections.Multidrug-resistant Gram-negative bacteria in solid organ transplant recipients with bacteremias.Recent developments in antibiotic agents for the treatment of complicated intra-abdominal infections.Dual effect of chloramphenicol peptides on ribosome inhibition.Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia.What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles.Inhibition of protein synthesis but not β-adrenergic receptors blocks reconsolidation of a cocaine-associated cue memory.Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms.The slow dissociation rate of K-1602 contributes to the enhanced inhibitory activity of this novel alkyl-aryl-bearing fluoroketolide.Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.Virtual screening of traditional Chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-tRNA synthetase.Multidrug-resistant bacteria in organ transplantation: an emerging threat with limited therapeutic options.Development and characterization of a Pseudomonas aeruginosa in vitro coupled transcription-translation assay system for evaluation of translation inhibitors.Safety, tolerability, and pharmacokinetics of oral and intravenous administration of GSK1322322, a peptide deformylase inhibitor.Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy.
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Antibiotics in development targeting protein synthesis.
@en
Antibiotics in development targeting protein synthesis.
@nl
type
label
Antibiotics in development targeting protein synthesis.
@en
Antibiotics in development targeting protein synthesis.
@nl
prefLabel
Antibiotics in development targeting protein synthesis.
@en
Antibiotics in development targeting protein synthesis.
@nl
P2860
P1476
Antibiotics in development targeting protein synthesis.
@en
P2093
Joyce A Sutcliffe
P2860
P304
P356
10.1111/J.1749-6632.2011.06323.X
P407
P577
2011-12-01T00:00:00Z