Kinetochores and disease: keeping microtubule dynamics in check!
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Regulation of kinetochore-microtubule attachments through homeostatic control during mitosisBasic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules.Inducible fluorescent speckle microscopyTubulin bond energies and microtubule biomechanics determined from nanoindentation in silico.Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila OocytesThe tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesionSpindle microtubule dysfunction and cancer predispositionHepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis.Accurate chromosome segregation by probabilistic self-organisation.Microtubule capture by mitotic kinesin centromere protein E (CENP-E).Microtubule-depolymerizing kinesin KLP10A restricts the length of the acentrosomal meiotic spindle in Drosophila femalesMitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in MitosisCdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachmentsNuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.De novo pathogenic variants in CHAMP1 are associated with global developmental delay, intellectual disability, and dysmorphic facial featuresEnd-binding proteins sensitize microtubules to the action of microtubule-targeting agents.Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors.Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments.Upregulation of centromere protein H is associated with progression of renal cell carcinoma.Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.The Ska complex promotes Aurora B activity to ensure chromosome biorientation.Balancing the kinetochore ledger.G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells.Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
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P2860
Kinetochores and disease: keeping microtubule dynamics in check!
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Kinetochores and disease: keeping microtubule dynamics in check!
@en
Kinetochores and disease: keeping microtubule dynamics in check!
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type
label
Kinetochores and disease: keeping microtubule dynamics in check!
@en
Kinetochores and disease: keeping microtubule dynamics in check!
@nl
prefLabel
Kinetochores and disease: keeping microtubule dynamics in check!
@en
Kinetochores and disease: keeping microtubule dynamics in check!
@nl
P2860
P1476
Kinetochores and disease: keeping microtubule dynamics in check!
@en
P2093
Duane A Compton
Samuel F Bakhoum
P2860
P356
10.1016/J.CEB.2011.11.012
P577
2011-12-21T00:00:00Z