The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.
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Ion channels as drug targets in central nervous system disordersRetigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 MutationsPolarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit.Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis.Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy.Protective role of Kv7 channels in oxygen and glucose deprivation-induced damage in rat caudate brain slices.Antiepileptic drugs 2012: recent advances and trends.One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression.Efficacy of retigabine in adjunctive treatment of partial onset seizures in adults.Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice.The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy.Potassium channels: a review of broadening therapeutic possibilities for neurological diseases.Current and emerging treatments for absence seizures in young patientsProgress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).Age-dependent Electroencephalographic Differences in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) Model of Absence Epilepsy.Efficacy of Retigabine on Acute Limbic Seizures in Adult Rats.The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome.The preclinical discovery and development of ezogabine for the treatment of epilepsy.Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.A resurging boom in new drugs for epilepsy and brain disorders.Modeling Neurovascular Disorders and Therapeutic Outcomes with Human-Induced Pluripotent Stem Cells.Activation of KCNQ channels located on the skeletal muscle membrane by retigabine and its influence on the maximal muscle force in rat muscle strips.
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P2860
The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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artigo científico
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The spectrum of anticonvulsant ...... implications for clinical use.
@en
The spectrum of anticonvulsant efficacy of retigabine
@nl
type
label
The spectrum of anticonvulsant ...... implications for clinical use.
@en
The spectrum of anticonvulsant efficacy of retigabine
@nl
prefLabel
The spectrum of anticonvulsant ...... implications for clinical use.
@en
The spectrum of anticonvulsant efficacy of retigabine
@nl
P2093
P2860
P1433
P1476
The spectrum of anticonvulsant ...... implications for clinical use.
@en
P2093
Astrid Nehlig
Charles H Large
Christopher S Crean
David M Sokal
H Steve White
Kevan E Vanlandingham
Martin J Gunthorpe
Raman Sankar
P2860
P304
P356
10.1111/J.1528-1167.2011.03364.X
P577
2012-01-05T00:00:00Z