Preclinical in vivo ADME studies in drug development: a critical review. - Wikidata - awgldk - TriplyDB

Preclinical in vivo ADME studies in drug development: a critical review.

Preclinical in vivo ADME studies in drug development: a critical review.

http://www.wikidata.org/entity/Q37976124

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World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development Antifungal drug discovery: the process and outcomes.Fluorescence imaging for a noninvasive in vivo toxicity-test using a transgenic silkworm expressing green fluorescent protein Cynomolgus macaques naturally infected with Trypanosoma cruzi-I exhibit an overall mixed pro-inflammatory/modulated cytokine signature characteristic of human Chagas disease The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract.Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing.The debate on animal ADME studies in drug development: an update.In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans.The High Cost of Stroke and Stroke Cytoprotection Research.Insecticide ADME for support of early-phase discovery: combining classical and modern techniques.Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

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Preclinical in vivo ADME studies in drug development: a critical review.

http://www.wikidata.org/entity/Q37976124

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Preclinical in vivo ADME studies in drug development: a critical review.

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Preclinical in vivo ADME studies in drug development: a critical review.

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Preclinical in vivo ADME studies in drug development: a critical review.

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Preclinical in vivo ADME studies in drug development: a critical review.

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Preclinical in vivo ADME studies in drug development: a critical review.

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Preclinical in vivo ADME studies in drug development: a critical review.

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17425255.2012.652084

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Expert Opinion on Drug Metabolism & Toxicology

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Preclinical in vivo ADME studies in drug development: a critical review.

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Mario Pellegatti

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

The Simcyp population-based ADME simulator

Membrane transporters in drug development

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs.

Accelerator mass spectrometry-enabled studies: current status and future prospects.

Metabolic disposition of casopitant, a potent neurokinin-1 receptor antagonist, in mice, rats, and dogs.

Physicochemical factors associated with binding and retention of compounds in ocular melanin of rats: correlations using data from whole-body autoradiography and molecular modeling for multiple linear regression analyses.

Food and drug administration's critical path initiative and innovations in drug development paradigm: Challenges, progress, and controversies.

Drug metabolites in safety testing.

Whole-body autoradiography in drug discovery.

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161-172

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10.1517/17425255.2012.652084

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22248306

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