Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy.
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The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motilitypH- and sodium-induced changes in a sodium/proton antiporter.Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair.PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathwaysIncreased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.Prolactin Signaling Stimulates Invasion via Na(+)/H(+) Exchanger NHE1 in T47D Human Breast Cancer CellsGlycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer questionFluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: dissection of intracellular signaling pathwaysThe human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na+/H+ Exchanger FunctionCation-coupled bicarbonate transportersChaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1.Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions.Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment.Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research.CD44 targets Na(+)/H(+) exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2.Regulation and roles of bicarbonate transporters in cancer.Intracellular pH in the resistance vasculature: regulation and functional implications.Inside out: targeting NHE1 as an intracellular and extracellular regulator of cancer progression.Cell volume regulation in epithelial physiology and cancerNa(+) dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies.Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment.Role of pHi, and proton transporters in oncogene-driven neoplastic transformation.Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development.Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.Negative News: Cl- and HCO3- in the Vascular Wall.Functional role of arginine 425 in the mammalian Na⁺/H⁺ exchanger.Characterization of human mutations in phosphorylatable amino acids of the cytosolic regulatory tail of SLC9A1.Membrane androgen receptor sensitive Na+/H+ exchanger activity in prostate cancer cells.Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer.Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancerMCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism.The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening.Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms.Acid-base regulation and sensing: Accelerators and brakes in metabolic regulation of cerebrovascular tone.Extracellular acidosis and very low [Na+ ] inhibit NBCn1- and NHE1-mediated net acid extrusion from mouse vascular smooth muscle cells.Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer.
P2860
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P2860
Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
@sq
artículo científico
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name
Physiology, pharmacology and p ...... plications for cancer therapy.
@en
Physiology, pharmacology and p ...... plications for cancer therapy.
@nl
type
label
Physiology, pharmacology and p ...... plications for cancer therapy.
@en
Physiology, pharmacology and p ...... plications for cancer therapy.
@nl
prefLabel
Physiology, pharmacology and p ...... plications for cancer therapy.
@en
Physiology, pharmacology and p ...... plications for cancer therapy.
@nl
P1476
Physiology, pharmacology and p ...... mplications for cancer therapy
@en
P2093
P304
P356
10.2174/138161212799504830
P577
2012-01-01T00:00:00Z