Organotypic systems in drug metabolism and toxicity: challenges and opportunities. - Wikidata - awgldk - TriplyDB

Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

http://www.wikidata.org/entity/Q38013255

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Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening.Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures.Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment.Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue.Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.Non-alcoholic fatty liver disease (NAFLD) models in drug discovery.Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis.

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Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

http://www.wikidata.org/entity/Q38013255

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Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

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Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

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Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

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17425255.2012.693161

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Expert Opinion on Drug Metabolism & Toxicology

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Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

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Ajit Dash

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Brett R Blackman

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Brian R Wamhoff

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P2860

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Can the pharmaceutical industry reduce attrition rates?

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow.

Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI.

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming.

Identification of differentially expressed genes in hepatocyte/endothelial cell co-culture system.

Cell patterning technologies for organotypic tissue fabrication.

Liver regeneration.

A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

Liver tissue engineering in the evaluation of drug safety.

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999-1014

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scholarly article

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10.1517/17425255.2012.693161

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8

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22632603

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