Using Drosophila models of neurodegenerative diseases for drug discovery.

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Discovery of trypanosomatid parasites in globally distributed Drosophila species.The power and richness of modelling tauopathies in Drosophila.Modelling tauopathies in Drosophila: insights from the fruit fly.

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Using Drosophila models of neurodegenerative diseases for drug discovery.

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http://www.wikidata.org/entity/Q38014579

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article científic

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article scientifique

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artikel ilmiah

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Using Drosophila models of neurodegenerative diseases for drug discovery.

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Using Drosophila models of neurodegenerative diseases for drug discovery.

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Using Drosophila models of neurodegenerative diseases for drug discovery.

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Using Drosophila models of neurodegenerative diseases for drug discovery

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Alex Johnston

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Amrit Mudher

http://www.w3.org/2001/XMLSchema#string

Christopher Sinadinos

http://www.w3.org/2001/XMLSchema#string

Megan Sealey

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P2860

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

A Drosophila model of Parkinson's disease

Biologically active molecules that reduce polyglutamine aggregation and toxicity.

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129-140

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scholarly article

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10.1517/17460441.2011.549124

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English

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http://www.w3.org/2001/XMLSchema#string

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http://www.w3.org/2001/XMLSchema#string

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Tracey A Newman

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2011-02-01T00:00:00Z

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22647132

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P921

neurodegeneration

Drosophila

Using Drosophila models of neurodegenerative diseases for drug discovery.

about

P2860

P2860

Using Drosophila models of neurodegenerative diseases for drug discovery.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921