Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.
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GSK-3 as potential target for therapeutic intervention in cancerAdvances in targeting signal transduction pathwaysPotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersInhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic deathChemical metabolic inhibitors for the treatment of blood-borne cancersUse of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activationDeregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Metformin: Midlife maturity, maiden charmProteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberinePentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.Integration of Different "-omics" Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia CellsBiguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transportA Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies.AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts.
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P2860
Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.
description
article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Targeting the liver kinase B1/ ...... or hematological malignancies.
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type
label
Targeting the liver kinase B1/ ...... or hematological malignancies.
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prefLabel
Targeting the liver kinase B1/ ...... or hematological malignancies.
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P2860
P50
P1476
Targeting the liver kinase B1/ ...... or hematological malignancies.
@en
P2093
Alberto M Martelli
Alessandra Cappellini
Andrea Ognibene
Anna Maria Billi
Daniela Bressanin
Lucia Manzoli
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P304
P356
10.1517/14728222.2012.694869
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P577
2012-06-12T00:00:00Z