Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin.
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Targeting p97 to Disrupt Protein Homeostasis in CancerThe ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.Mutations in the Human AAA+ Chaperone p97 and Related DiseasesProteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97Control of p97 function by cofactor bindingPerilous journey: a tour of the ubiquitin-proteasome systemThe requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubilityThe Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutationsUSP7 is a SUMO deubiquitinase essential for DNA replicationDynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionConcerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.Regulation of the DNA damage response by ubiquitin conjugation.Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.Ter94/VCP is a novel component involved in BMP signalingShedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD)Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Structure and function of the AAA+ ATPase p97/Cdc48p.Role of p97/VCP (Cdc48) in genome stability.A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosisCdc48: a swiss army knife of cell biology.Emerging mechanistic insights into AAA complexes regulating proteasomal degradation.Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.Spatiotemporal regulation of posttranslational modifications in the DNA damage response.Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer.The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damageRole of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction.The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation.Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.Terminating the replication helicase.Functional characterization of the chaperon-like protein Cdc48 in cryptogein-induced immune response in tobacco.Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.
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P2860
Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Growing sphere of influence: C ...... ent extraction from chromatin.
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type
label
Growing sphere of influence: C ...... ent extraction from chromatin.
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prefLabel
Growing sphere of influence: C ...... ent extraction from chromatin.
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P1476
Growing sphere of influence: C ...... ent extraction from chromatin.
@en
P304
P356
10.1016/J.TCB.2012.06.003
P577
2012-07-19T00:00:00Z