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Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein–Protein InteractionOptimized S -Trityl- l -cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft ModelsTriphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor ActivityDesign and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)Large-scale ligand-based predictive modelling using support vector machinesIdentification of a Small Molecule Inhibitor of RAD52 by Structure-Based SelectionFrom a library of MAG antagonists to nanomolar CD22 ligands.Recent trends and observations in the design of high-quality screening collections.Cellular membrane phospholipids act as a depository for quaternary amine containing drugs thus competing with the acetylcholine/nicotinic receptor.Antifungal drug discovery: the process and outcomes.Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicityRepurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Determination of lipophilicity of γ-butyrolactone derivatives with anticonvulsant and analgesic activity using micellar electrokinetic chromatography.Interactions of platinum and ruthenium coordination complexes with pancreatic phospholipase A(2) and phospholipids investigated by MALDI TOF mass spectrometry.Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductaseMLP Tools: a PyMOL plugin for using the molecular lipophilicity potential in computer-aided drug design.Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.Metronidazole-triazole conjugates: activity against Clostridium difficile and parasitesIdentification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives.Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffoldHeteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter.Synthesis of 4-aryl-6-indolylpyridine-3-carbonitriles and evaluation of their antiproliferative activity.Boron-containing inhibitors of synthetases.The influence of the 'organizational factor' on compound quality in drug discovery.Lead-oriented synthesis: a new opportunity for synthetic chemistry.The right compound in the right assay at the right time: an integrated discovery DMPK strategy.System-based drug discovery within the human kinome.Developing new antibacterials through natural product research.Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research.Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.Selective sigma-1 receptor antagonists for the treatment of pain.Aptamers as targeted therapeutics: current potential and challenges.The impact of binding thermodynamics on medicinal chemistry optimizations.Pharmaceuticals that contain polycyclic hydrocarbon scaffolds.Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Lipophilicity in drug discovery.
@en
type
label
Lipophilicity in drug discovery.
@en
prefLabel
Lipophilicity in drug discovery.
@en
P2860
P1476
Lipophilicity in drug discovery.
@en
P2093
Michael J Waring
P2860
P304
P356
10.1517/17460441003605098
P407
P577
2010-03-01T00:00:00Z