Improvement of drug-like properties of peptides: the somatostatin paradigm.
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Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsTargeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide ConjugationCyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis.Microwave and continuous flow technologies in drug discovery.N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation.Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy.Non-invasive iontophoretic delivery of peptides and proteins across the skin."Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery.Review cyclic peptides on a merry-go-round; towards drug design.Review backbone N-modified peptides: How to meet the challenge of secondary amine acylation.Peptidomimetic therapeutics: scientific approaches and opportunities.Metabolism and disposition of the αv-integrin ß3/ß5 receptor antagonist cilengitide, a cyclic polypeptide, in humans.Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3',5'difluorophenyl)-alanine.Peptide bicycles that inhibit the Grb2 SH2 domain.Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leads.The influence of solvent on conformational properties of peptides with Aib residue-a DFT study.Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility.Insights into structure-activity relationships of somatostatin analogs containing mesitylalanine.Fine-tuning the π-π aromatic interactions in peptides: somatostatin analogues containing mesityl alanine.Metabolic stability of peptidomimetics: N-methyl and aza heptapeptide analogs of a PKB/Akt inhibitor.The impact of model peptides on structural and dynamic properties of egg yolk lecithin liposomes - experimental and DFT studies.
P2860
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P2860
Improvement of drug-like properties of peptides: the somatostatin paradigm.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Improvement of drug-like properties of peptides: the somatostatin paradigm.
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type
label
Improvement of drug-like properties of peptides: the somatostatin paradigm.
@en
prefLabel
Improvement of drug-like properties of peptides: the somatostatin paradigm.
@en
P2093
P2860
P1476
Improvement of drug-like properties of peptides: the somatostatin paradigm.
@en
P2093
Amnon Hoffman
Burkhardt Laufer
Chaim Gilon
Horst Kessler
Oded Ovadia
Sarit Greenberg
P2860
P304
P356
10.1517/17460441.2010.493935
P407
P577
2010-06-03T00:00:00Z