New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
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Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1TFPI1 mediates resistance to doxorubicin in breast cancer cells by inducing a hypoxic-like responseLXY6090 - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibitionPalladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategyExosomal Proteome Profiling: A Potential Multi-Marker Cellular Phenotyping Tool to Characterize Hypoxia-Induced Radiation Resistance in Breast Cancer.In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer.N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro.A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.An internal ribosome entry site in the 5' untranslated region of epidermal growth factor receptor allows hypoxic expressionInduction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cellsNovel and emerging targeted-based cancer therapy agents and methods.Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis.Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models.Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo.Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization.Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast CancerThe BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal CancerIncreased chemosensitivity and radiosensitivity of human breast cancer cell lines treated with novel functionalized single-walled carbon nanotubesNovel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions.Cell volume regulation in epithelial physiology and cancerThe influence of pH and hypoxia on tumor metastasis.Bicarbonate transport in health and disease.Designing carbonic anhydrase inhibitors for the treatment of breast cancer.Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells.The unfolded protein response in glioblastomas: targetable or trouble?Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic function.Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis.Expression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc.RAS protein activator-like 1 is functionally involved in hypoxia resistance in breast cancer cells by targeting hypoxia inducible factor-1α.Propofol suppresses LPS-induced nuclear accumulation of HIF-1α and tumor aggressiveness in non-small cell lung cancer.Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors.Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration.Novel sulfonamide compounds for inhibition of metastatic tumor growth (WO2012021963).A systematic quantitative approach to rational drug design and discovery of novel human carbonic anhydrase IX inhibitors.Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation.CoCl2 increases the expression of hypoxic markers HIF-1α, VEGF and CXCR4 in breast cancer MCF-7 cells.Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness.
P2860
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P2860
New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
@en
type
label
New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
@en
prefLabel
New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
@en
P2093
P1476
New strategies for targeting the hypoxic tumour microenvironment in breast cancer.
@en
P2093
Carol Ward
Claudiu T Supuran
Ian H Kunkler
Peter Mullen
Simon P Langdon
P304
P356
10.1016/J.CTRV.2012.08.004
P577
2012-10-12T00:00:00Z