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Crystallographic insights into sodium-channel modulation by the β4 subunitDiscovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.The hitchhiker's guide to the voltage-gated sodium channel galaxyThe clinical approach to small fibre neuropathy and painful channelopathyAn update on transcriptional and post-translational regulation of brain voltage-gated sodium channelsNav1.7 and other voltage-gated sodium channels as drug targets for pain reliefA de novo gain-of-function mutation in SCN11A causes loss of pain perceptionLocating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channelGlobal Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to painCarbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic painModeling nociception in zebrafish: a way forward for unbiased analgesic discoveryInhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of PainInfantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese FamiliesEvaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currentsSelective spider toxins reveal a role for the Nav1.1 channel in mechanical painSubtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.Upregulation of nav1.7 through high salt loading: (mol pain 2013;9:39)Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathyThe tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Voltage-gated Na+ currents in human dorsal root ganglion neurons.Structure-based assessment of disease-related mutations in human voltage-gated sodium channels.Association of Polymorphisms in Pharmacogenetic Candidate Genes with Propofol Susceptibility.High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE.Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.Skin matters: identifying pain mechanisms and predicting treatment outcomes.Linkage between increased nociception and olfaction via a SCN9A haplotypeModulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats.Lost but making progress--Where will new analgesic drugs come from?Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacNovel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations.Dissection of voltage-gated sodium channels in developing cochlear sensory epithelia.Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin.Selective conversion of fibroblasts into peripheral sensory neurons.Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.Novel sodium channel antagonists in the treatment of neuropathic pain.Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The Na(V)1.7 sodium channel: from molecule to man.
@en
type
label
The Na(V)1.7 sodium channel: from molecule to man.
@en
prefLabel
The Na(V)1.7 sodium channel: from molecule to man.
@en
P2093
P356
P1476
The Na(V)1.7 sodium channel: from molecule to man
@en
P2093
Joel A Black
Stephen G Waxman
Sulayman D Dib-Hajj
P2888
P356
10.1038/NRN3404
P407
P577
2012-12-12T00:00:00Z
P6179
1015083703