Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.
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4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activitiesMutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsAlternatives to currently used antimalarial drugs: in search of a magic bulletDiscovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.Quinolone-3-diarylethers: a new class of antimalarial drug.Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparumInhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapyNew paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.Targeting the redox metabolism of Plasmodium falciparum.Novel inhibitors of the Plasmodium falciparum electron transport chain.Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria.Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.Antimalarial drug discovery: where next?Message from the editors.Isoxazole mediated synthesis of 4-(1H)pyridones: improved preparation of antimalarial candidate GSK932121.Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo.
P2860
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P2860
Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Exploration of 4(1H)-pyridones ...... the plasmodial cytochrome bc1.
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type
label
Exploration of 4(1H)-pyridones ...... the plasmodial cytochrome bc1.
@en
prefLabel
Exploration of 4(1H)-pyridones ...... the plasmodial cytochrome bc1.
@en
P2093
P2860
P356
P1476
Exploration of 4(1H)-pyridones ...... the plasmodial cytochrome bc1.
@en
P2093
Domingo Gargallo-Viola
Esperanza Herreros
Francisco J Gamo
Geo Derimanov
Iñigo Angulo-Barturen
José M Bueno
José M Fiandor
Santiago Ferrer
P2860
P304
P356
10.4155/FMC.12.177
P577
2012-12-01T00:00:00Z