Biosynthesis of thiopeptide antibiotics and their pathway engineering.
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Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptidesCatalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosLThe crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substratesNocardiopsis species: a potential source of bioactive compounds.Total Synthesis of Nosiheptide.Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system.Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis.Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteriaPhosphoserine Lyase Deoxyribozymes: DNA-Catalyzed Formation of Dehydroalanine Residues in Peptides.Elucidating and engineering thiopeptide biosynthesis.Recombinant thiopeptides containing noncanonical amino acids.The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffoldsAn α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization.Thiopeptide engineering: a multidisciplinary effort towards future drugs.YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics.Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ.Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo.Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.Ribosomal Natural Products, Tailored To Fit.Expansion of chemical space for natural products by uncommon P450 reactions.Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt Products.Insight into bicyclic thiopeptide biosynthesis benefited from development of a uniform approach for molecular engineering and production improvement
P2860
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P2860
Biosynthesis of thiopeptide antibiotics and their pathway engineering.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Biosynthesis of thiopeptide antibiotics and their pathway engineering.
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type
label
Biosynthesis of thiopeptide antibiotics and their pathway engineering.
@en
prefLabel
Biosynthesis of thiopeptide antibiotics and their pathway engineering.
@en
P2860
P356
P1476
Biosynthesis of thiopeptide antibiotics and their pathway engineering.
@en
P2093
P2860
P304
P356
10.1039/C2NP20107K
P577
2013-02-01T00:00:00Z