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Regulation of kinetochore-microtubule attachments through homeostatic control during mitosisAneuploidy in pluripotent stem cells and implications for cancerous transformationFive Questions (with their Answers) on ER-Associated DegradationMitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical UtilityMyo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division.Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndromeInner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability.The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcomeRegulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosisMCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation.Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability.Topoisomerase IIα in chromosome instability and personalized cancer therapy.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Protein degradation corrects for imbalanced subunit stoichiometry in OST complex assembly.Streptococcus gallolyticus infection in colorectal cancer and association with biological and clinical factors.Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ MiceIdentification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma.Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers.Multi-layered cancer chromosomal instability phenotype.GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival.Tumor hypoxia as a driving force in genetic instability.Aneuploidy: implications for protein homeostasis and diseaseCohesin in cancer: chromosome segregation and beyond.Functionality of the chromosomal passenger complex in cancer.How to count chromosomes in a cell: An overview of current and novel technologies.Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues.The Role of Aneuploidy in Cancer Evolution.Chromosomal Instability in Gastric Cancer Biology.Mechanisms regulating immune surveillance of cellular stress in cancer.Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.Kinetochore Malfunction in Human Pathologies.Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer.APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The cancer biology of whole-chromosome instability.
@en
type
label
The cancer biology of whole-chromosome instability.
@en
prefLabel
The cancer biology of whole-chromosome instability.
@en
P2860
P356
P1433
P1476
The cancer biology of whole-chromosome instability
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2012.616
P407
P577
2013-01-14T00:00:00Z
P5875
P6179
1028735655